�A Johns Hopkins enquiry team reports it may have an explanation for at least some of the higher organ rejection rates seen among black as compared to tweed kidney graft recipients.
In a study of 50 goodly adult hands, 25 black and 25 white, importantly different amounts of certain immune arrangement cells were found between the races.
These cells, known as human leukocyte antigen-specific, or HLA-specific B cells, when "hypersensitive" produce antibodies linked to transplanted kidney rejection, says Andrea Zachary, professor of medicine at Johns Hopkins and lead researcher of the study.
It's been foresightful known that HLA-reactive antibodies produced by B cells are one of the ways that transplanted organs are jilted. Zachary developed a novel method for counting HLA-specific B cells more accurately, leading to the hypothesis that B cell book of Numbers make a difference in transplant retentivity and rejection.
"Now that we have an accurate way to bet these cells, we ar able to confirm what we tenacious suspected, that blacks might have a bigger army of HLA-specific B cells," says Zachary who presented her findings at the Congress of the International Transplant Society in Sydney, Australia on Aug. 12.
Zachary says that patients turn sensitized when exposed to HLA in blood or tissue that is non their have. Sensitized HLA-specific B cells then produce antibodies that attack transplanted organs containing foreign HLA. Patients tin become sensitised from a blood blood transfusion, transplantation or pregnancy.
"If the recipient is not hypersensitized, B cells represent simply a patient's potential for making antibodies," says Zachary. "However around a third of patients in motive of a kidney are sensitized since they're often on their second or third transplanting and may have undergone transfusions. In the written report, Zachary and her squad gathered blood samples from 25 adult black males and 25 adult albumen males. They were all healthy and all non-sensitized. They as well gathered stock samples from 10 sensitized adult disastrous males and 25 supersensitive white males.
Results showed that the bleak non-sensitized males tested had an average of 17.2 per centum more HLA-sensitive B cells than the white non-sensitized males time-tested. Among the sensitized chemical group, black males had an average of 22.9 percent more HLA-sensitive B cells than white males.
HLA antigens are proteins that sit on the surface of origin and tissue paper cells. Each person has a specific set, standardized to a fingerprint. Rejection of a transplant occurs when the recipient's immune system sees the donor's HLA antigens as alien and attacks those antigens with cells or antibodies. The amount of antibody made depends on the number of B cells a recipient has.
"Knowing that blacks have an increased number of HLA-specific B cells - which increases their opportunity for antibody-mediated rejection - we may be able to custom-make treatments for black recipients to account for these differences and lessen the likelihood that the organ will be rejected," says Zachary.
Additional Johns Hopkins researchers who worked on this study ar Mary S. Leffell, Ph.D.; and Dessislava Kopchaliifka, Ph.D., of the Department of Medicine and J. Keith Melancon, M.D., of the Department of Surgery.
Johns Hopkins Medicine
901 S Bond St., Ste. 550
Baltimore, MD 21231
United States
http://www.hopkinsmedicine.org
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Tuesday 9 September 2008
Saturday 30 August 2008
Video-game reviews: "Soulcalibur IV" and "The Bourne Conspiracy"
Battle it out with Yoda or Bourne in two modern fighting games.
"Soulcalibur IV"
"Soulcalibur IV" may not be the quintessential one-on-one fighting game, but it's certainly the quintessential "Soulcalibur."
It features the most various lineup, the most extensive character-building options and by far the best art of whatsoever recent combat game.
Plus, Yoda is in the Xbox 360 version, and Darth Vader is playable for those with the PS3 edition. Another "Star Wars" character makes an visual aspect in both versions as well: Vader's secret learner from the upcoming "Force Unleashed" game. They all play well � Yoda dips and spins, Vader employs crushing blows and Force attacks and the Apprentice is quick and powerful with unpredictable strikes.
The game play is what one expects from a fighting-game sequel: familiar simply with tweaks. Fighters cause new moves, and some old moves have been replaced or require different motions to carry out.
Fighters now experience three pieces of protective equipment that can be shattered during battle, and a type that blocks too much can expression an instant-kill attack.
The story mode cuts out a lot of the extraneous map piloting and early annoyances of previous "Soulcaliburs." The downside is that the narrative is all but lost.
Character creation is where the game very shines. "Soulcalibur III" introduced the concept, but it's refined here. Players can create characters using earned items and any of the main cast's scrap styles and weapons.
The options are sparse, but "Soulcalibur IV" allows for on-line play, victimization a well-done queue system for players waiting for a match.
System: Microsoft Xbox 360 and Sony PlayStation 3
Price: $59.99
Age rating: Teen
"The Bourne Conspiracy"
"The Bourne Conspiracy" serves as the banner model of how to construct a good game based on a movie.
It offers something beyond the events of the movie, and the game play is strong enough to stand on its own.
Though Matt Damon's alikeness is nowhere to be found, the character models and voices are well-done. Each mission is either based on an action sequence from the start movie or takes position as a flashback mission covering events not seen in the movies.
Though he'll occasionally take to the streets for a car chase, amnesiac assassin Bourne spends to the highest degree of his time taking out enemies with a selection of guns or bruising hand-to-hand combat. This is where the secret plan rocks.
After a few rounds of punches and kicks with a foe, Bourne's adrenaline metre gains a level so he stern pull off powerful takedown moves. If he has more than one adrenaline level, he can dispatch multiple foes.
Takedowns are perchance too unproblematic to manipulation, but they're fun to watch and surprisingly varied � "Bourne" will use different maneuvers, depending on his position relative to his opposer and whatsoever objects ar nearby.
System: Xbox 360 and PlayStation 3
Price: $59.99
Age rating: Teen
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Wednesday 20 August 2008
Kanye West Joins Lil Wayne, Bemoans Nine Inch Nails Face-Off At Virgin Fest
BALTIMORE � Fans got more than they bargained for at this weekend's Virgin Mobile Festival � more Kanye, anyway.
Not depicted object to close out the two-day festival with his headlining Sunday slot, Mr. West stormed the stage earlier in the day, joining Lil Wayne for a meeting of hip-hop's hottest. Maybe 'Ye was pulling doubled duty to outshine the legends (Bob Dylan, Iggy and the Stooges), heavy rock veterans (Foo Fighters, Stone Temple Pilots, Nine Inch Nails, Offspring), and upstarts (Paramore, Jack Johnson, Duffy) wHO took the Virgin stage over the weekend at Pimlico Race Course.
Rocking a Louis Vuitton backpack, West joined Weezy on Sunday afternoon to spit his verse from the "Lollipop" remix without skipping a beat. The collabo was the high-energy point of a blistery, better-late-than-never performance. Showing up a 30 minutes late for an hourlong set would be a cardinal hell for almost artists, merely Weezy more than made up for it. The crowd chanted his identify and even booed in short while waiting for his set, simply it was all making love once Lil Wayne hit the stage. Wayne came with a mix of old-school, new-school and a lot of gratitude. "How many of y'all got Tha Carter III?" he asked. "I f---in' appreciate you."
He even took time to honor Static Major, asking for a minute of silence for the late rapper and songster before jumping into the song that catapulted Wayne from an underground mixtaper to an undeniable mainstream superstar. After welcoming Kanye up for "Lollipop," Wayne wrapped his set with even more than gratitude and some laughs, lip-syncing to Whitney Houston's "I Will Always Love You" earlier leaving the stage.
While Wayne's day was done, Kanye was simply getting started. He returned to the stage later that night like a hurricane, shrouded in flashing lights and fog. Fans threw up their Roc-A-Fella diamonds early and held them high all night. No irony was disoriented on 'Ye, who made it a point to prove his authenticity in front jumping into "Diamonds From Sierra Leone."
"I work real hard at this rapping sh--," he said. "This is real rap."
Kanye dove into a set spanning his entire career, from his most recent verse from Young Jeezy's "Put On" to his humble beginnings on "All Comes Down," asking fans to "scream so loud I can't see the music" if they knew the song.
And, of course, 'Ye talked, touch on everything from his mother's last to Barack Obama's nomination to criminal offence in the festival's host city of Baltimore. He freestyled as well, expressing his gratitude for fame and his frustration that comes along with it. The in the raw emotion was undeniable. "I lost my mama/ I went through so lots drama/ I went through so much drama/ I'm for Obama," he rapped. He then described his journey over to Pimlico Race Course, noting the flashing blasphemous lights supra cameras stationed throughout the 'hood and being content with the fact that even though many Baltimore natives couldn't afford to attend the concert, they could still see and hear the show from the parking lot outside the bill Gates. He as well shouted taboo MySpace, the Internet and Lil Wayne before beginning "Touch the Sky."
West took a bit of a jab at the festival's schedule, specifically the choice concertgoers had to make between his performance and one from Nine Inch Nails happening at the same clock time at the other end of the park (a dilemma faced by fans at Chicago's Lollapalooza a week to begin with). "It's not a black-or-white thing, it's not a rap-or-rock-and-roll thing," he exclaimed. "It's a good-music thing. We jam about good things from the heart. How can you cull between me and Trent Reznor?"
But at the end of the day, Kanye's focus all came back down to his fans. Again freestyling, 'Ye expressed his zeal to please those wHO came out to support him. "I hope you had a good time ... f--- that, the time of your life!" And with diamonds high in the sky and screams that could be heard around the block, the crowd's enthusiasm matched Kanye's (no easy feat).
The solar day before, it was up to West's fellow Chi-Town native Lupe Fiasco, wHO had fans bobbing their heads and singing on to "Superstar" and "Kick, Push." Despite technical difficulties, Lupe aimed to please, shouting subsequently his mike problem was resolved, "Let's hype this bitch back up, all right?" Given the measure of crowd-surfing during his set and the loudness of fans chanting his name when he left the stage, he seemed to succeed.
But the weekend wasn't all about hip-hop. The Foos, the Stooges, Paramore and NIN brought the rock, but the guitar heroes of the day power have been Stone Temple Pilots. Taking the microscope stage later than expected (thanks, Weezy), STP seemed to be the picture of reunification. The band was completely in sync thanks to its current 65-date tour. The focus wasn't mainly on themselves, though. Scott Weiland shared the love, cheering out those sharing the bill. "What a great day of f---ing music!," he gushed. "How about Iggy and the Stooges? And Nine Inch Nails are approach up!" He also had love for the crowd. "What a sea of energy," he exclaimed scarcely before the crowd american ginseng and bobbed along to every eminence of the band's breakthrough hit "Plush."
For more sights and stories from concerts around the country, retard out MTV News Tour Reports. And send your own concert pics, videos and reviews to MTV News You R Here!
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Sunday 10 August 2008
Ralph Lundsten
Artist: Ralph Lundsten
Genre(s):
Ambient
New Age
Discography:
Pe Drumbda Stigar
Year: 2004
Tracks: 18
De Drumda Stigar
Year: 2004
Tracks: 18
Dreamlight Cd2
Year: 2003
Tracks: 15
Dreamlight Cd1
Year: 2003
Tracks: 17
Music For Relaxation and Meditation
Year: 2001
Tracks: 10
The Seasons
Year: 1996
Tracks: 9
The Joy Of Being
Year: 1994
Tracks: 12
Nordic Light
Year: 1993
Tracks: 14
Ralphinated Symphonies
Year: 1992
Tracks: 8
Mindscape Music
Year: 1992
Tracks: 2
Lyckolegend and En Midvintersaga
Year: 1992
Tracks: 8
Lustbarheter
Year: 1992
Tracks: 13
Elderstrappan
Year: 1990
Tracks: 18
Nordic Nature Symphony No 2 Johannes And The Lady Ofthe Woods Op. 99
Year: 1988
Tracks: 11
Nordic Nature Symphony No 1 The Water Sprite Op. 75 1972
Year: 1988
Tracks: 9
Horrorscope
Year: 1988
Tracks: 15
Dancing In The New Age
Year: 1988
Tracks: 14
Romance In The New Age
Year: 1987
Tracks: 12
Paradise Symphony
Year: 1987
Tracks: 7
Nordic Nature Symphony No 4 and No 5 A Summer Saga Bewitched
Year: 1987
Tracks: 10
Nordic Nature Symphony No 3 A Midwinter Saga
Year: 1987
Tracks: 7
Cosmic Phantazy
Year: 1987
Tracks: 2
Nordiska Natursymfonier
Year: 1974
Tracks: 4
Midnight Hour and Other Works
Year: 1973
Tracks: 15
Svit Elektroniskt Dragspel
Year: 1968
Tracks: 4
Feel It
Year: 1968
Tracks: 2
The Ages Of Man
Year:
Tracks: 8
Pat Vingliga Tar
Year:
Tracks: 6
Inspiration Sweden - Landscape Of Dream
Year:
Tracks: 13
Diskophrenia Remixes (SVEK 023)
Year:
Tracks: 4
Wednesday 2 July 2008
Saturday 14 June 2008
Bill's Wife -- Kid CaddyWhacker?
Bill Murray isn't the only Murray who gets lit and lets it out on the kids -- allegedly.Murray's wife Jennifer Butler-Murray was pinched by the po-po in South Carolina on March 17 after allegedly getting drunk -- and then violent with her kids, according to a report filed with the Sullivan's Island Police. A witness caught Jennifer yelling at one of the couple's kids, and the cop who cornered her wrote that she was "very impaired."
Butler-Murray's been blabbing in a divorce filing that Bill was addicted to booze and drugs, abused, abandoned, and "lucky he didn't kill her."
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Monday 9 June 2008
Britney's dad becomes her full time conservator
Washington (ANI): Britney Spears has become a full-time priority for her dad Jamie Spears, for he has now quit his catering job and is devoting all his time to look after his daughter"s affairs, court papers have revealed. Thus, Spears senior was handed over a sum of 10,000 dollars as back pay for covering up the month of his co-conservatorship of her estate, which started on Feb. 1. He even started getting a 2,500-dollar weekly salary beginning in March. "The responsibilities he has assumed as conservator ... have required [his] full-time attention," People quoted the request for "replacement compensation," as saying. It further read: "As a result, he has been unable to continue to his prior employment and he has lost his source of income which he needs to pay his living expenses."
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